Structure of alphacoronavirus transmissible gastroenteritis virus nsp1 has implications for coronavirus nsp1 function and evolution.
Identifieur interne : 001854 ( Main/Exploration ); précédent : 001853; suivant : 001855Structure of alphacoronavirus transmissible gastroenteritis virus nsp1 has implications for coronavirus nsp1 function and evolution.
Auteurs : Anna M. Jansson [Suède]Source :
- Journal of virology [ 1098-5514 ] ; 2013.
Descripteurs français
- KwdFr :
- Alignement de séquences, Cristallographie aux rayons X, Données de séquences moléculaires, Expression des gènes, Modèles moléculaires, Pliage des protéines, Protéines virales non structurales (), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), RNA replicase (), RNA replicase (génétique), RNA replicase (métabolisme), Structure secondaire des protéines, Structure tertiaire des protéines, Séquence d'acides aminés, Virus de la gastroentérite transmissible (), Virus de la gastroentérite transmissible (génétique).
- MESH :
- génétique : Protéines virales non structurales, RNA replicase, Virus de la gastroentérite transmissible.
- métabolisme : Protéines virales non structurales, RNA replicase.
- Alignement de séquences, Cristallographie aux rayons X, Données de séquences moléculaires, Expression des gènes, Modèles moléculaires, Pliage des protéines, Protéines virales non structurales, RNA replicase, Structure secondaire des protéines, Structure tertiaire des protéines, Séquence d'acides aminés, Virus de la gastroentérite transmissible.
English descriptors
- KwdEn :
- Amino Acid Sequence, Crystallography, X-Ray, Gene Expression, Models, Molecular, Molecular Sequence Data, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, RNA Replicase (chemistry), RNA Replicase (genetics), RNA Replicase (metabolism), Sequence Alignment, Transmissible gastroenteritis virus (chemistry), Transmissible gastroenteritis virus (classification), Transmissible gastroenteritis virus (genetics), Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , chemistry : RNA Replicase, Viral Nonstructural Proteins.
- chemical , genetics : RNA Replicase, Viral Nonstructural Proteins.
- chemical , metabolism : RNA Replicase, Viral Nonstructural Proteins.
- chemistry : Transmissible gastroenteritis virus.
- classification : Transmissible gastroenteritis virus.
- genetics : Transmissible gastroenteritis virus.
- Amino Acid Sequence, Crystallography, X-Ray, Gene Expression, Models, Molecular, Molecular Sequence Data, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Alignment.
Abstract
Coronavirus nsp1 has been shown to induce suppression of host gene expression and to interfere with the host immune response. However, the mechanism is currently unknown. The only available structural information on coronavirus nsp1 is the nuclear magnetic resonance (NMR) structure of the N-terminal domain of nsp1 from severe acute respiratory syndrome coronavirus (SARS-CoV) from the betacoronavirus genus. Here we present the first nsp1 structure from an alphacoronavirus, transmissible gastroenteritis virus (TGEV) nsp1. It displays a six-stranded β-barrel fold with a long alpha helix on the rim of the barrel, a fold shared with SARS-CoV nsp1(13-128). Contrary to previous speculation, the TGEV nsp1 structure suggests that coronavirus nsp1s have a common origin, despite the lack of sequence homology. However, comparisons of surface electrostatics, shape, and amino acid conservation between the alpha- and betacoronaviruses lead us to speculate that the mechanism for nsp1-induced suppression of host gene expression might be different in these two genera.
DOI: 10.1128/JVI.03163-12
PubMed: 23269811
Affiliations:
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Jansson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden. anna.jansson@icm.uu.se</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Crystallography, X-Ray</term><term>Gene Expression</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Protein Folding</term><term>Protein Structure, Secondary</term><term>Protein Structure, Tertiary</term><term>RNA Replicase (chemistry)</term><term>RNA Replicase (genetics)</term><term>RNA Replicase (metabolism)</term><term>Sequence Alignment</term><term>Transmissible gastroenteritis virus (chemistry)</term><term>Transmissible gastroenteritis virus (classification)</term><term>Transmissible gastroenteritis virus (genetics)</term><term>Viral Nonstructural Proteins (chemistry)</term><term>Viral Nonstructural Proteins (genetics)</term><term>Viral Nonstructural Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Cristallographie aux rayons X</term><term>Données de séquences moléculaires</term><term>Expression des gènes</term><term>Modèles moléculaires</term><term>Pliage des protéines</term><term>Protéines virales non structurales ()</term><term>Protéines virales non structurales (génétique)</term><term>Protéines virales non structurales (métabolisme)</term><term>RNA replicase ()</term><term>RNA replicase (génétique)</term><term>RNA replicase (métabolisme)</term><term>Structure secondaire des protéines</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term><term>Virus de la gastroentérite transmissible ()</term><term>Virus de la gastroentérite transmissible (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA Replicase</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Replicase</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA Replicase</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales non structurales</term><term>RNA replicase</term><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales non structurales</term><term>RNA replicase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Crystallography, X-Ray</term><term>Gene Expression</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Protein Folding</term><term>Protein Structure, Secondary</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Cristallographie aux rayons X</term><term>Données de séquences moléculaires</term><term>Expression des gènes</term><term>Modèles moléculaires</term><term>Pliage des protéines</term><term>Protéines virales non structurales</term><term>RNA replicase</term><term>Structure secondaire des protéines</term><term>Structure tertiaire des protéines</term><term>Séquence d'acides aminés</term><term>Virus de la gastroentérite transmissible</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus nsp1 has been shown to induce suppression of host gene expression and to interfere with the host immune response. However, the mechanism is currently unknown. The only available structural information on coronavirus nsp1 is the nuclear magnetic resonance (NMR) structure of the N-terminal domain of nsp1 from severe acute respiratory syndrome coronavirus (SARS-CoV) from the betacoronavirus genus. Here we present the first nsp1 structure from an alphacoronavirus, transmissible gastroenteritis virus (TGEV) nsp1. It displays a six-stranded β-barrel fold with a long alpha helix on the rim of the barrel, a fold shared with SARS-CoV nsp1(13-128). Contrary to previous speculation, the TGEV nsp1 structure suggests that coronavirus nsp1s have a common origin, despite the lack of sequence homology. However, comparisons of surface electrostatics, shape, and amino acid conservation between the alpha- and betacoronaviruses lead us to speculate that the mechanism for nsp1-induced suppression of host gene expression might be different in these two genera.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>East Middle Sweden</li><li>Svealand</li></region><settlement><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Jansson, Anna M" sort="Jansson, Anna M" uniqKey="Jansson A" first="Anna M" last="Jansson">Anna M. Jansson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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